Faculty and Research Interests
  

Douglas D. Frey, Ph.D. Professor of Chemical & Biochemical Engineering University of Maryland Baltimore County  1000 Hilltop Circle  Baltimore, MD 21250  phone: (410) 455-3418  fax: (410) 455-1049  email: dfrey1@umbc.edu website: Faculty Web Site

Education: 
Ph.D., Chemical Engineering, University of California, Berkeley, 1984 
M.S., Chemical Engineering, University of California, Berkeley, 1980 
B.S., Chemical Engineering, Stanford University, 1978

 

Employment History: 
Professor, University of Maryland Baltimore County, 2001-present

Director, Separation Processes Program, NSF, 2001-3, 2005-6

Department Chairman, University of Maryland Baltimore County, 1995-2000

Associate Professor, University of Maryland Baltimore County, 1993-2001

Associate Professor, Yale University, 1990-93 
Assistant Professor,  Yale University, 1984-90 
 
Research Areas: 
Separation methods in biotechnology and proteomics, protein purification, chromatography and electrophoresis of biopolymers, biomedical applications of analytical chromatography, adsorption of biopolymers to surfaces, transport processes in porous media. 

Selected Recent Publications: 
D. D. Frey and X. Kang, "New Concepts in the Chromatography of Peptides and Proteins," Curr. Opin. Biotechnol., 18, 552-560, 2005.

J. Soto Pérez, D. D. Frey, "Behavior of the Inadvertant pH Transient Formed by a Salt Gradient in the Ion-Exchange Chromatography of Proteins," Biotechnol. Progr., 21, 902-910, 2005.

H. Shen, D. D. Frey, "Effect of Charge Regulation on Steric Mass-Action Equilibrium for the Ion-Exchange Adsorption of Proteins," J. Chromatogr. A, 1079, 92-104, 2005. 

X. Kang, D. D. Frey, "Chromatofocusing of Peptides and Proteins Using Linear pH Gradients Formed on Strong Ion-Exchange Adsorbents," Biotechnol. Bioeng., 87, 376-387, 2004.

H. Shen, D. D. Frey, "Charge Regulation in Protein Ion-Exchange Chromatography: Development and Experimental Evaluation of a Theory Based on Hydrogen Ion Donnan Equilibrium," J. Chromatogr. A, 1034, 55-68, 2004. 

X. Kang, D. D. Frey, "High-Performance Cation-Exchange Chromatofocusing of Proteins,"  J. Chromatogr. A, 991, 117-128, 2003. 

X. Kang, D. D. Frey "Chromatofocusing Using Micropellicular Column Packings with Computer-Aided Design of the Elution Buffer Composition," Anal. Chem., 74, 1038-1045, 2002.

D. D. Frey, C. R. Narahari, C. D. Butler, "General Local-Equilibrium Chromatographic Theory for Eluents Containing Adsorbing Buffers," AIChE J., 48, 561-571, 2002. 

D. Farnan, D. D. Frey, Cs. Horváth, "Surface and Pore Diffusion in Macroporous and Gel-Filled Gigaporous Stationary Phases for Protein Chromatography," J. Chromatogr. A, 959, 65-73, 2002. 

 

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